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Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
Chondroitin sulfate; Dermatan sulfate; Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine ...
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage , and also play key roles in neural development and glial scar formation.
Chondroitin sulfate/dermatan sulfate (CSGAGs) which along with HSGAGs are synthesized in the Golgi apparatus, where protein cores, made in the rough endoplasmic reticulum, are post-translationally modified via O-linked glycosylation by glycosyltransferases, thus forming proteoglycans.
Use of chondroitin in routine clinical practice should therefore be discouraged." Also in 2007, Bruyere et al. [45] without using explicit methodology for reviewing trials concluded "there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA." The effectiveness of glucosamine is controversial.
Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.