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Budiodarone (ATI-2042) is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials.Amiodarone is considered the most effective antiarrhythmic drug available, [1] [2] [3] but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, [4] are discouraging its use.
ATC code C01 Cardiac therapy is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup C01 is part of the anatomical group C Cardiovascular system. [4]
Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart. [8] It was pulled from the market in 1967 due to side effects. [9] In 1974 it was found to be useful for arrhythmias and reintroduced. [9] It is on the World Health Organization's List of Essential Medicines. [10]
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
The Alamogordo Code Enforcement Department and Sides were awarded the 2023 Jill Robinson Award by the Code Enforcement Officer Safety Foundation and the Presidential Certificate of Recognition.
Code 1: A time critical event with response requiring lights and siren. This usually is a known and going fire or a rescue incident. Code 2: Unused within the Country Fire Authority. Code 3: Non-urgent event, such as a previously extinguished fire or community service cases (such as animal rescue or changing of smoke alarm batteries for the ...
A Drug Recognition Expert (DRE) is a law enforcement officer trained in a scientifically validated method to identify people whose driving is impaired by drugs other than, or in addition to, alcohol. All DREs follow the same 12 step procedure called a Drug Influence Evaluation (DIE), to purportedly determine which category of drugs is causing ...
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]