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The highest rates of HPV are in younger women, with a rate of 24% in women under 25 years. [183] Rates decline in older age groups in Europe and the Americas, but less so in Africa and Asia. The rates are highest in Sub-Saharan Africa (24%) and Eastern Europe (21%) and lowest in North America (5%) and Western Asia (2%).
Rates are falling fastest among women in their early 20s, the first generation to benefit from HPV vaccines, which were approved in 2006. HPV, the human papillomavirus, causes six types of cancer ...
A 2007 survey of American women found 40% had heard of HPV infection and less than half of those knew it causes cervical cancer. [175] Over a longitudinal study from 1975 to 2000, it was found that people of lower socioeconomic census brackets had higher rates of late-stage cancer diagnosis and higher morbidity rates.
Many women with HPV infection never develop CIN or cervical cancer. Typically, HPV resolves on its own. [4] However, those with an HPV infection that lasts more than one or two years have a higher risk of developing a higher grade of CIN. [5] Like other intraepithelial neoplasias, CIN is not cancer and is usually curable. [3]
Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. [1] Several hundred species of papillomaviruses, traditionally referred to as "types", [2] have been identified infecting all carefully inspected mammals, [2] but also other vertebrates such as birds, snakes, turtles and fish.
Although 90% of HPV infections are cleared by the body within two years of infection, it is possible for infected cells to undergo a latency (quiet) period, with the first occurrence or a recurrence of symptoms happening months or years later. [4] Latent HPV, even with no outward symptoms, is still transmissible to a sexual partner.
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This is associated with carcinogenic genotypes of HPV and/or HPV persistence factors such as cigarette smoking or immunocompromised states. Differentiated vulvar intraepithelial neoplasia also known as VIN Simplex: is associated with vulvar dermatoses such as lichen sclerosus. It is associated with atypia of the squamous epithelium. [4] [5]