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  2. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    Recently, a link between cholinergic neuronal activity and the activity of alpha-secretase has been highlighted, [19] which can discourage amyloid-beta proteins deposition in brain of patients with Alzheimer's disease. Alzheimer's disease has been identified as a protein misfolding disease, or proteopathy, due to the accumulation of abnormally ...

  3. Experimental models of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Experimental_models_of...

    Alzheimer's disease is a progressive neurodegenerative disorder associated with aging, which occurs both sporadically (the most common form of diagnosis) or due to familial passed mutations in genes associated with Alzheimer's pathology. [1] [2] Common symptoms associated with Alzheimer's disease include: memory loss, confusion, and mood ...

  4. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...

  5. Silent brain changes precede Alzheimer's. Researchers have ...

    www.aol.com/news/silent-brain-changes-precede...

    Compared to those who remained cognitively healthy, people who eventually developed the mind-robbing disease had higher levels of an Alzheimer's-linked protein in their spinal fluid 18 years prior ...

  6. Default mode network - Wikipedia

    en.wikipedia.org/wiki/Default_mode_network

    People with Alzheimer's disease show a reduction in glucose (energy use) within the areas of the default mode network. [4] These reductions start off as slight decreases in patients with mild symptoms and continue to large reductions in those with severe symptoms.

  7. Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Alzheimer's_disease

    Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]