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Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is ...
Hirano bodies are found in the nerve cells of individuals afflicted with certain neurodegenerative disorders, such as Alzheimer's disease and Creutzfeldt–Jakob disease. [ 3 ] Hirano bodies were first described in the CA1 in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC). [ 2 ]
Age-related neuropathologies such as Alzheimer's disease, Parkinson's disease, diabetes, hypertension and arteriosclerosis make it difficult to distinguish the normal patterns of aging. [18] [19] One of the important differences between normal aging and pathological aging is the location of neurofibrillary tangles.
Accurate whole brain parcellation may lead to more accurate macroscale connectomes for the normal brain, which can then be compared to disease states. Pathways through cerebral white matter can be charted by histological dissection and staining , by degeneration methods, and by axonal tracing .
In 2016, an MIT study found that memory loss in early stages of Alzheimer's disease could be reversed by strengthening specific memory engram cell connections in the brains of Alzheimer mouse models. [12]
The atlas was created to enhance research in many neuroscience research fields including neuropharmacology, human brain imaging, human genetics, neuroanatomy, genomics and more. The atlas is also geared toward furthering research into mental health disorders and brain injuries such as Alzheimer's disease, autism, schizophrenia and drug addiction.
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. [2] It is the cause of 60–70% of cases of dementia. [2] [15] The most common early symptom is difficulty in remembering recent events. [1]
The onset of the deficits has been between the ages of 40 and 90 years and finally there must be an absence of other diseases capable of producing a dementia syndrome. Possible Alzheimer's disease: There is a dementia syndrome with an atypical onset, presentation or progression; and without a known etiology; but no co-morbid diseases capable of ...