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Alpha-2 blocker. Alpha-2 blockers (or α2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α 2 adrenergic receptor. They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs ...
Alpha blockers work by blocking the effect of nerves in the sympathetic nervous system. This is done by binding to the alpha receptors in smooth muscle or blood vessels. [37] α-blockers can bind both reversibly and irreversibly. [2] There are several α receptors throughout the body where these drugs can bind.
Adrenergic blocking agent. Adrenergic blocking agents are a class of drugs that exhibit its pharmacological action through inhibiting the action of the sympathetic nervous system [1] in the body. The sympathetic nervous system (SNS) is an autonomic nervous system that we cannot control by will. It triggers a series of responses after the body ...
Adrenergic neuron blockers. Adrenergic neurone blockers, commonly known as adrenergic antagonists, are a group of drugs that inhibit the sympathetic nervous system by blocking the activity of adrenergic neurones. They prevent the action or release of catecholamines such as norepinephrine and epinephrine. They are located throughout the body ...
In Wikidata. Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor has two subclasses α 1 and α 2. Alpha 2 receptors are associated with sympatholytic properties. Alpha-adrenergic agonists have the opposite function of alpha blockers.
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the G i heterotrimeric G-protein. It consists of three highly homologous subtypes, including α 2A -, α 2B -, and α 2C -adrenergic. Some species other than humans express a fourth α 2D -adrenergic receptor as well. [1]
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [ 1 ] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, [ 1 ] but also 5-HT 3, [ 1 ] 5-HT 6, and/or 5-HT 7 in some cases.
Those that block beta-2-adrenergic receptors reduce blood pressure through increased relaxation of smooth muscle. [33] Alpha-blockers can block alpha-1 adrenergic receptors and/or alpha-2 adrenergic receptors. [34] Those that block alpha-1-adrenergic receptors on vascular smooth muscle cells prevent vasoconstriction. [34]