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2003: Excedrin Tension Headache contains 500 mg acetaminophen, and 65 mg caffeine. 2005: Excedrin Sinus Headache contains 325 mg acetaminophen and 5 mg phenylephrine HCl as a decongestant. 2007: Excedrin Back and Body – a dual-ingredient formula claiming that it "works two ways—as a pain reliever and a pain blocker right where it hurts".
Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol. Studies have reached conflicting conclusions regarding the clinical significance of this incremental pain relief. [20] [21]
Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
Tylenol (/ ˈ t aɪ l ə n ɒ l /) is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol (known in the United States, Canada, and various other countries as acetaminophen ), an ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic properties.