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Drusen, from the German word for node or geode (singular, "Druse"), are tiny yellow or white accumulations of extracellular material that build up between Bruch's membrane and the retinal pigment epithelium of the eye. The presence of a few small ("hard") drusen is normal with advancing age, and most people over 40 have some hard drusen. [1]
Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. [1] Early on there are often no symptoms. [1] Over time, however, some people experience a gradual worsening of vision that may affect one or both eyes. [1]
Retinoschisis is an eye disease characterized by the abnormal splitting of the retina's neurosensory layers, usually in the outer plexiform layer.Retinoschisis can be divided into degenerative forms which are very common and almost exclusively involve the peripheral retina and hereditary forms which are rare and involve the central retina and sometimes the peripheral retina.
The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400-450 square micrometers (μm 2). The smallest plaques (less than 200 μm 2), which often consist of diffuse deposits of Aβ, [4] are particularly numerous. [6]
The most severe brain atrophy appears to be associated with behavioral variant FTD, and corticobasal degeneration. [ 42 ] With regard to the genetic defects that have been found, repeat expansion in the C9orf72 gene is considered a major contribution to FTLD, although defects in the GRN and MAPT genes are also associated with it.
This nucleus is known for its large number of multipolar cells and its particularly reticular structure. The reticulotegmental nucleus is topographically related to pontine nuclei (non-reticular), being just dorsal to them. The reticulotegmental nucleus has been known to mediate eye movements, otherwise known as saccadic movement. [1]
The paramedian pontine reticular formation (PPRF) is a subset of neurons of the oral and caudal pontine reticular nuclei. With the abducens nucleus it makes up the horizontal gaze centre . [ 1 ] It is situated in the pons adjacent to the abducens nucleus . [ 2 ]
The reticular formation is a set of interconnected nuclei in the brainstem that spans from the lower end of the medulla oblongata to the upper end of the midbrain. [2] The neurons of the reticular formation make up a complex set of neural networks in the core of the brainstem. [3]