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In particular, the level of Sic1, a stoichiometric inhibitor of Clb-CDK complexes in budding yeast, was shown to be particularly important in irreversible G1-S transition by irreversibly activating S phase kinases. [27] Sic1 level was shown to play a major role in triggering irreversible mitotic exit (M-G1 transition) as well as in G1-S transition.
In physics, chemistry, and other related fields like biology, a phase transition (or phase change) is the physical process of transition between one state of a medium and another. Commonly the term is used to refer to changes among the basic states of matter : solid , liquid , and gas , and in rare cases, plasma .
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
In biology, phase variation is a method for dealing with rapidly varying environments without requiring random mutation. It involves the variation of protein expression, frequently in an on-off fashion, within different parts of a bacterial population. As such the phenotype can switch at frequencies that are much higher (sometimes >1%) than ...
Hysteresis of Cdk1 activity via cyclin B drives M phase entry by establishing a minimum threshold of cyclin B concentration. This exists at a level higher than the minimum needed for the continuation of M phase after entry, acting to safeguard the all-or-nothing event.
Conversely, a phase reversal or phase inversion implies a 180-degree phase shift. [2] When the phase difference () is a quarter of turn (a right angle, +90° = π/2 or −90° = 270° = −π/2 = 3π/2), sinusoidal signals are sometimes said to be in quadrature, e.g., in-phase and quadrature components of a composite signal or even different ...
Chemical potentials are important in many aspects of multi-phase equilibrium chemistry, including melting, boiling, evaporation, solubility, osmosis, partition coefficient, liquid-liquid extraction and chromatography. In each case the chemical potential of a given species at equilibrium is the same in all phases of the system.
In biology, a biological life cycle (or just life cycle when the biological context is clear) is a series of stages of the life of an organism, that begins as a zygote, often in an egg, and concludes as an adult that reproduces, producing an offspring in the form of a new zygote which then itself goes through the same series of stages, the ...