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Brain metastasis: neurological symptoms such as headaches, [10] seizures, [10] and vertigo [10] Although advanced cancer may cause pain, it is often not the first symptom. Some patients, however, do not show any symptoms. [10] When the organ gets a metastatic disease it begins to shrink until its lymph nodes burst, or undergo lysis.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. [3] [4] Cancer can be difficult to diagnose because its signs and symptoms are often nonspecific, meaning they may be general phenomena that do not point directly to a specific disease process.
Micrograph showing a colorectal carcinoma metastasis to the cerebellum. HPS stain. A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [1] [2] The metastasis typically shares a cancer cell type with the original site of the cancer. [3]
The origin of the term "Virchow's Triad" is of historical interest, and has been subject to reinterpretation in recent years. [7] While both Virchow's and the modern triads describe thrombosis, the previous triad has been characterized as "the consequences of thrombosis", and the modern triad as "the causes of thrombosis".
Clinically, CNS metastasis is known to cause haemorrhage or obstruction in the cranial portion of the CNS leading to hydrocephalus. [ 9 ] Additionally, metastatic lesions are usually discrete within the brain and appear as spherical masses that displace the brain parenchyma rather than invading the tissues. [ 10 ]
Some malignancies, especially gliomas (25%), as well as adenocarcinomas of the pancreas and lung, are associated with hypercoagulability (the tendency to form blood clots) for reasons that are incompletely understood, but may be related to factors secreted by the tumors, in particular a circulating pool of cell-derived tissue factor-containing microvesicles. [7]
Surgery for metastatic disease: If metastatic disease is present surgical treatment may still a viable option. Radical and partial nephrectomy can still occur, and in some cases, if the metastasis is small this can also be surgically removed. [10] This depends on what stage of growth and how far the disease has spread.
Lymph node metastasis is the spread of cancer cells into a lymph node.. Lymph node metastasis is different from malignant lymphoma.Lymphoma is a cancer of lymph node, rather than cancer in the lymph node, because lymphoma originates from the lymph node itself, instead of originating elsewhere (e.g., the breast or colon) and spreading to the lymph nodes.