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Mepacrine, also called quinacrine or by the trade names Atabrine or Atebrin, is a medication with several uses. It is related to chloroquine and mefloquine . Although available from compounding pharmacies , as of August 2020 approved formulations are not available in the United States.
More severe side effects include deafness, low blood platelets, and an irregular heartbeat. [5] Use can make one more prone to sunburn. [5] While it is unclear if use during pregnancy carries potential for fetal harm, treating malaria during pregnancy with quinine when appropriate is still recommended. [5]
Micrograph of fatty liver, as may be seen due to long-term prednisone use. Trichrome stain.. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. [24]
Neuropsychiatric quinism is a chronic encephalopathy due to intoxication by mefloquine, quinacrine, chloroquine. It is associated with brain dysfunction and brainstem dysfunction. It may be confused as posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI).
There is one study supporting the use of a novel combination of dextromethorphan and low dose quinidine in alleviating symptoms of easy laughing and crying (pseudobulbar affect); these are a type of rather severe uncontrollable behaviors which can be present in various neurological pathologies such as amyotrophic lateral sclerosis and multiple sclerosis.
The term "steroid dementia" was coined by Varney et al. (1984) in reference to the effects of long-term glucocorticoid use in 1,500 patients. [3] While the condition generally falls under the classification of Cushing's syndrome , the term "steroid dementia syndrome" is particularly useful because it recognizes both the cause of the syndrome ...
Regarding non-cardiac side effects, they can cause nausea, headache, fatigue, dry mouth, and dry eyes. [4] In rare cases, confusion , memory loss , and sexual dysfunction are reported. [ 12 ] Additionally, beta 1 blockers can mask hypoglycaemia-induced tachycardia in diabetic patients, potentially leading to hypoglycaemic unawareness and ...
Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. [2] Though, the World Health Organization (WHO) in 2013 recommended use for seasonal preventive in children at high risk in combination with sulfadoxine and pyrimethamine. [4] Amodiaquine is a 4-aminoquinoline compound related to chloroquine. [2]