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Hemoglobin A2 (HbA 2) is a normal variant of hemoglobin A that consists of two alpha and two delta chains (α 2 δ 2) and is found at low levels in normal human blood.Hemoglobin A2 may be increased in beta thalassemia or in people who are heterozygous for the beta thalassemia gene.
Hemoglobin, alpha 2 [5] also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin. [6] [7] Function. The human alpha globin gene ...
Hemoglobin A (HbA), also known as adult hemoglobin, hemoglobin A1 or α 2 β 2, is the most common human hemoglobin tetramer, accounting for over 97% of the total red blood cell hemoglobin. [1] Hemoglobin is an oxygen-binding protein, found in erythrocytes , which transports oxygen from the lungs to the tissues. [ 2 ]
Hemoglobin Portland II (ζ 2 β 2). In fetuses: Hemoglobin F (α 2 γ 2; In neonates (newborns inmmediately after birth): Hemoglobin A (adult hemoglobin) (α 2 β 2 ) – The most common with a normal amount over 95%; Hemoglobin A 2 (α 2 δ 2) – δ chain synthesis begins late in the third trimester and, in adults, it has a normal range of 1. ...
The normal hemoglobin types are Hemoglobin A (HbA), which makes up 95–98% of total hemoglobin in adults, Hemoglobin A2 (HbA2), which constitutes 2–3% of total hemoglobin in adults, and Hemoglobin F (HbF), which is the predominant hemoglobin in the fetus during pregnancy, and may persist in small amounts in adults. [1]
Two alpha chains plus two beta chains constitute HbA, which in normal adult life accounts for about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with fetal hemoglobin (HbF), composed of alpha and gamma chains, make up the remaining 3% of adult hemoglobin. [6]
Fetal hemoglobin, or foetal haemoglobin (also hemoglobin F, HbF, or α 2 γ 2) is the main oxygen carrier protein in the human fetus. Hemoglobin F is found in fetal red blood cells , and is involved in transporting oxygen from the mother's bloodstream to organs and tissues in the fetus.
A healthy level of hemoglobin for men is between 13.2 and 16.6 grams per deciliter, and in women between 11.6 and 15 g/d. [19] Normal adult hemoglobin is composed of four protein chains, two α and two β-globin chains arranged into a heterotetramer.