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Anthelmintic medication is also used in mass deworming campaigns of school-aged children in many developing countries. [2] [3] Anthelmintics are also used for mass deworming of livestock. The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; [4] for schistosomiasis and tapeworms it is praziquantel. [5]
Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; [4] they are usually effective against a limited number of parasites within a particular class. Antiparasitics are one of the antimicrobial drugs which include antibiotics that target bacteria, and antifungals that target fungi.
This therapy ties to the Hygiene hypothesis in that the lack of exposure to bacteria and parasites such as helminths can cause a weaker immune system leading to being more susceptible to autoimmune disease. [4] [5] Helminth worms are members of two phyla: nematodes, which are primarily used in human helminthic therapy, and flat worms . [2]
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. [5] This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid disease, among others. [5] It has been used for treatment of giardiasis but is not a preferred agent.
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