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Heartburn is a common symptom of late term pregnancy during which up to 80% of pregnant women have experienced it by the end of their third trimester. [12] Heartburn often indicates the development of gastro-esophageal reflux disease (GERD), where the lower esophageal sphincter relaxes due to elevated progesterone levels causing increased ...
Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. [4]
Up to 20% of aluminium from ingested antacid salts can be absorbed from the gastrointestinal tract – despite some unverified concerns about the neurological effects of aluminium, [11] aluminium phosphate and hydroxide salts are thought to be safe as antacids in normal use, even during pregnancy and breastfeeding. [12] [11]
Use appears to be safe in pregnancy and breastfeeding. [6] How it works is unclear but is believed to involve binding to the ulcer and protecting it from further damage. [3] [6] Sucralfate was approved for medical use in the United States in 1981. [3] It is available as a generic medication.
Calcium-based antacids are recommended if these changes are not effective; aluminum- and magnesium hydroxide-based antacids are also safe. [73] Antacids that contain sodium bicarbonate or magnesium trisilicate should be avoided in pregnancy. [73] Sucralfate has been studied in pregnancy and proven to be safe [73] as is ranitidine [74] and PPIs ...
It appears to be safe during pregnancy but has not been well studied in this group. [8] It is a serotonin 5-HT 3 receptor antagonist. [8] It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia. [11] Ondansetron was patented in 1984 and approved for medical use in 1990. [12]
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