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Brain natriuretic peptide (BNP), also known as B-type natriuretic peptide, is a hormone secreted by cardiomyocytes in the heart ventricles in response to stretching caused by increased ventricular blood volume. [5] BNP is one of the three natriuretic peptides, in addition to atrial natriuretic peptide and C-type natriuretic peptide ( CNP). [6]
BNP was first discovered in pig brain tissue but was later found more abundant in the heart (Mukoyama et al. 1991; Mukoyama et al. 1990). The human gene that encodes for BNP is called NPPB (GeneID 4879) and is located on chromosome 1 at 1p36.2. In mice, NPPb is found on chromosome 4. [3]
It agreed to pay $8.9 billion, the largest fine ever for violating U.S. sanctions, and substantially more than the previous record of $1.9 billion. [33] [60] BNP Paribas was also barred for one year under the plea agreement from certain US dollar-dominated transactions. The fine exceeded the bank's $6.4 billion 2013 annual income and the $1.1 ...
The highest natural ground surface temperature ever recorded may have been an alleged reading of 93.9 °C (201.0 °F) at Furnace Creek, California, United States, on 15 July 1972. [7] In 2011, a ground temperature of 84 °C (183.2 °F) was recorded in Port Sudan , Sudan. [ 8 ]
2012 Haida Gwaii earthquake – magnitude 7.8 earthquake with an epicenter on Moresby Island in British Columbia, the second largest Canadian earthquake ever recorded by a seismometer, over 100,000 people were evacuated to higher ground in the state of Hawai'i
No one was ever charged with any of the murders. [55] Juan Corona United States: 1971 25 25+ Corona was convicted of murdering ranch laborers and burying them in orchards. He was sentenced to 25 terms life imprisonment. [56] Died from natural causes in 2019. Fritz Haarmann Germany: 1918–1924 24 27+
This is a list of countries showing past fertility rate, ranging from 1950 to 2015 in five-year periods, as estimated by the 2017 revision of the World Population Prospects database by the United Nations Population Division.
On the other hand, for films like Avengers: Age of Ultron and Captain America: Civil War which opened in several markets a week ahead of their respective releases in the US-Canada market, the 'opening' is the sum of the opening grosses in the markets where they were released first and the opening in the US-Canada market. In the latter case, the ...