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The cells were first noted by Henle in 1837 when studying the lining of the small intestine, seen to be mucus producing by Leydig in 1857 (who was examining the epidermis of fish), and were given their name by Schulze in 1867, [24] [25] Schulze chose the descriptive name "goblet" because of the shape of the cell, rather than a functional name ...
Microfold cells (commonly referred to as M cells) sample antigens from the lumen and deliver them to the lymphoid tissue associated with the mucosa (MALT). In the small intestine, M cells are associated with Peyer's patches. Cup cells are a distinct cell type that produces vimentin. [13] Tuft cells play a part in the immune response. [13]
21786 Ensembl ENSG00000160180 ENSMUSG00000024029 UniProt Q07654 Q62395 RefSeq (mRNA) NM_003226 NM_011575 RefSeq (protein) NP_003217 NP_035705 Location (UCSC) Chr 21: 42.31 – 42.32 Mb Chr 17: 31.34 – 31.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene. Function Members of the trefoil family are ...
During each mitosis, one of the two daughter cells remains in the crypt as a stem cell, while the other differentiates and migrates up the side of the crypt and eventually into the villus. These stem cells can differentiate into either an absorptive ( enterocytes ) or secretory ( Goblet cells , Paneth cells , enteroendocrine cells ) lineages. [ 3 ]
The muscle of the inner layer is arranged in circular rings around the tract, whereas the muscle of the outer layer is arranged longitudinally. The stomach has an extra layer, an inner oblique muscular layer. [1] Between the two muscle layers is the myenteric plexus (Auerbach's plexus). This controls peristalsis.
Goblet cell-associated antigen passages (GAP) transfer low molecular weight soluble antigens to CD103+ dendritic cells. CD103+ dendritic cells are associated with tolerance induction. [30] CX3CR1+ macrophages extend in between enterocytes and directly take up antigens form the intestinal lumen. These macrophages are not capable of traveling to ...
Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine and large intestine.
Unlike their neighbor cells, M cells have the unique ability to take up antigen from the lumen of the small intestine via endocytosis, phagocytosis, or transcytosis. Antigens are delivered to antigen-presenting cells, such as dendritic cells, and B lymphocytes. M cells express the protease cathepsin E, similar to other antigen-presenting cells ...