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A meta-analysis concluded that supplementation with β-carotene does not appear to decrease the risk of cancer overall, nor specific cancers including: pancreatic, colorectal, prostate, breast, melanoma, or skin cancer generally. [8] [40] High levels of β-carotene may increase the risk of lung cancer in current and former smokers.
Also downregulated is the enzyme beta-carotene 15,15'-dioxygenase (formerly known as beta-carotene 15,15'-monooxygenase) coded for by the BCMO1 gene, responsible for symmetrically cleaving β-carotene into retinal. [8] Absorbed β-carotene is either incorporated as such into chylomicrons or first converted to retinal and then retinol, bound to ...
Overconsumption of beta-carotene can only cause carotenosis, a harmless and reversible cosmetic condition in which the skin turns orange. Preformed vitamin A absorption and storage in the liver occur very efficiently until a pathologic condition develops. [21] When ingested, 70–90% of preformed vitamin A is absorbed and used. [21]
Also, some virus are co-carcinogens like Herpesviruses, Epstein–Barr virus (EBV) and human herpesvirus 4 (HHV-4) [9] Over intake beta carotene for a long period of time increased the risk of lung cancer, prostate cancer and many other kind of malignant tumor for cigarette smoker and worker having high contact with asbestos. [10]
α-Carotene is produced when the all-trans lycopene first undergoes reaction with epsilon-LCY then a second reaction with beta-LCY; whereas β-carotene is produced by two reactions with beta-LCY. α- and β-Carotene are the most common carotenoids in the plant photosystems but they can still be further converted into xanthophylls by using beta ...
The term carotene (also carotin, from the Latin carota, "carrot" [1] [2]) is used for many related unsaturated hydrocarbon substances having the formula C 40 H x, which are synthesized by plants but in general cannot be made by animals (with the exception of some aphids and spider mites which acquired the synthesizing genes from fungi). [3]
Like many products high in beta-carotene, it may cause temporary carotenoderma, a benign skin condition resulting in an orange-yellow hue to the skin. [ 1 ] [ better source needed ] Drinking more than 3 cups of carrot juice in a 24-hour period over a prolonged period of time may be enough to cause the condition.
In the human body, β-cryptoxanthin is converted to vitamin A and is, therefore, considered a provitamin A.As with other carotenoids, β-cryptoxanthin is an antioxidant and may help prevent free radical damage to cells and DNA, as well as stimulate the repair of oxidative damage to DNA.