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Bioinformatics is the name given to these mathematical and computing approaches used to glean understanding of biological processes. Common activities in bioinformatics include mapping and analyzing DNA and protein sequences, aligning DNA and protein sequences to compare them, and creating and viewing 3-D models of protein structures.
Bioinformatics and computational biology are interdisciplinary fields of research, development and application of algorithms, computational and statistical methods for management and analysis of biological data, and for solving basic biological problems.
Biological database design, development, and long-term management is a core area of the discipline of bioinformatics. [3] Data contents include gene sequences, textual descriptions, attributes and ontology classifications, citations, and tabular data.
European Bioinformatics Institute (EMBL-EBI) Swiss-Prot has collected over 81 000 variants in roughly 13,000 human protein sequence records from peer-reviewed literature. It is unclear how many unique proteins types are present in the database.
The journal Bioinformatics also introduced a Bioimage Informatics track in 2012. The OpenAccess journal BMC Bioinformatics has a section devoted to bioimage analysis, visualization and related applications. Other computational biology and bioinformatics journals also regularly publish bioimage informatics work. A European Union Cost action ...
Quality assessment of raw data [6] is the first step of the bioinformatics pipeline of RNA-Seq. Often, is necessary to filter data, removing low quality sequences or bases (trimming), adapters, contaminations, overrepresented sequences or correcting errors to assure a coherent final result.
Open Bioinformatics Foundation: BioPerl: Perl language toolkit Cross-platform: Artistic, GPL: Open Bioinformatics Foundation: BioPHP: PHP language toolkit with classes for DNA and protein sequence analysis, alignment, database parsing, and other bioinformatics tools Cross-platform: GPL v2 Open Bioinformatics Foundation: Biopython: Python ...
Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the three-dimensional structure of biological macromolecules such as proteins, RNA, and DNA. It deals with generalizations about macromolecular 3D structures such as comparisons of overall folds and local motifs, principles of molecular ...