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Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Nitrofurantoin, sold under the brand name Macrobid among others, is an antibacterial medication of the nitrofuran class used to treat urinary tract infections (UTIs), although it is not as effective for kidney infections. [16] It is taken by mouth. [16] Common side effects include nausea, loss of appetite, diarrhea, and headaches. [16]
The evidence that preventive antibiotics decrease urinary tract infections in children is poor. [72] However recurrent UTIs are a rare cause of further kidney problems if there are no underlying abnormalities of the kidneys, resulting in less than a third of a percent (0.33%) of chronic kidney disease in adults. [73]
Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. [3] Symptoms most often include fever and flank tenderness . [ 2 ] Other symptoms may include nausea , burning with urination , and frequent urination . [ 2 ]
Nitrofurantoin — a drug used to treat urinary tract infections [3] Ranbezolid — technically an oxazolidinone antibiotic bearing a nitrofuran group; Antimicrobials. Furaltadone — an antiprotozoal; Furazidine — an antibacterial and antiprotozoal Furaginum — an antibacterial; Furylfuramide — a formerly used food preservative
Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation.It often occurs in the glomerulus, where it is called glomerulonephritis.
The aim of treatment is to reduce renal scarring. Those children with grade II or worse should receive low dose prophylactic antibiotics (Nitrofurantoin, trimethoprim, cotrimoxazole, cefalexin in those with CRF). Hypertension should be managed with ACE inhibitor or ARBs. Other treatment modalities include surgery (endoscopic injection of ...
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.