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Schematic of the Philadelphia chromosome formation The chromosomal defect in the Philadelphia chromosome is a reciprocal translocation , in which parts of two chromosomes, 9 and 22, swap places. The result is that a fusion gene is created by juxtaposing the ABL1 gene on chromosome 9 (region q34) to a part of the BCR (breakpoint cluster region ...
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This image is a derivative work of the following images: File:Philadelphia_chromosome.jpg licensed with Cc-by-sa-2.5,2.0,1.0, Cc-by-sa-3.0-migrated, GFDL . 2007-01-16T00:35:50Z A Obeidat 401x211 (10412 Bytes) Philadelphia Chromosome Translocation
The first fusion gene [1] was described in cancer cells in the early 1980s. The finding was based on the discovery in 1960 by Peter Nowell and David Hungerford in Philadelphia of a small abnormal marker chromosome in patients with chronic myeloid leukemia—the first consistent chromosome abnormality detected in a human malignancy, later designated the Philadelphia chromosome. [3]
This abnormal chromosome was dubbed the Philadelphia chromosome - as both scientists were doing their research in Philadelphia, Pennsylvania. Thirteen years later, with the development of more advanced techniques, the abnormal chromosome was shown by Janet Rowley to be the result of a translocation of chromosomes 9 and 22. Identification of the ...
David A. Hungerford (1927–1993) was an American cancer researcher and co-discoverer of the Philadelphia chromosome. [1] This discovery was the first association between a genetic abnormality and a type of cancer, [2] and it changed the direction of cancer research and paved the way for the development of targeted cancer therapies.
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia.The chromosome 22 breakpoint for this translocation is located within the BCR gene.
The "e" is missing in the word "chromosome" in the schematic picture. Norman21 11:21, 25 December 2012 (UTC) Also, the schematic picture identifies the genes as abl and bcl, and although the lowercase letters are poor style, it's even worse style because it's actually BCR (Breakpoint Cluster Region) not BCL.
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