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The impairment of bone metabolism causes inadequate bone mineralization. Osteomalacia in children is known as rickets, and because of this, use of the term "osteomalacia" is often restricted to the milder, adult form of the disease. Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones.
An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result. [2] Symptoms of vitamin D toxicity may include the following: Dehydration; Vomiting; Diarrhea; Decreased appetite; Irritability; Constipation ...
In those with greater levels or rapid onset, symptoms may include abdominal pain, bone pain, confusion, depression, weakness, kidney stones or an abnormal heart rhythm including cardiac arrest. [1] [2] Most outpatient cases are due to primary hyperparathyroidism and inpatient cases due to cancer. [1]
Vitamin D also helps clear beta amyloid, a protein that plays a role in Alzheimer’s disease, Merrill points out. This is “the same mechanism targeted by new prescription drugs in Alzheimer’s ...
People who have had stomach surgery for weight loss, older adults, and people with gastrointestinal conditions like Crohn’s disease and celiac disease are also at risk for a B12 deficiency, she ...
Maternal vitamin D deficiency can cause fetal bone defects from before birth and impairment of bone quality after birth. [81] [82] Rickets typically appear between 3 and 18 months of age. [83] This condition can be caused by vitamin D, calcium or phosphorus deficiency. [84]
Since vitamin D is a fat-soluble vitamin, too much can put you at serious risk for toxicity including adverse side effects like kidney stones and high calcium levels in the blood.
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.