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Tar is toxic and damages the smoker's lungs over time through various biochemical and mechanical processes. [1] Tar also damages the mouth by rotting and blackening teeth, damaging gums, and desensitizing taste buds. Tar includes the majority of mutagenic and carcinogenic agents in tobacco smoke.
Iron imbalance locally in the lung thus results in higher risk of infection. Hemosiderin is the iron storage in smoker's macrophage rather than ferritin. It is formed during hemorrhage or abnormal metabolism of ferritin. [14] [15] Indeed, buildup of iron causes oxidative stress resulting in lung damage and mitochondrial dysfunction. [13]
It often takes several attempts, and potentially utilizing different approaches each time, before achieving long-term abstinence. Over 74.7% of smokers attempt to quit without any assistance, [24] otherwise known as "cold turkey", or with home remedies. Previous smokers make between an estimated 6 to 30 attempts before successfully quitting. [25]
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The association of smoking with lung cancer and COPD are among strongest, both in the public perception and etiologically. Among male smokers, the lifetime risk of developing lung cancer is 17.2%; among female smokers, the risk is 11.6%. This risk is significantly lower in nonsmokers: 1.3% in men and 1.4% in women. [26]
Smokers have a worse mood than they typically would have if they were not nicotine-dependent; they experience normal moods only immediately after smoking. [35] Nicotine dependence is associated with poor sleep quality and shorter sleep duration among smokers. [104] [105]
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