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Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some overlap in the terminology) [citation needed].
An inflammatory cytokine is a type of cytokine (a signaling molecule) that is secreted from immune cells and certain other cell types that promotes inflammation. Inflammatory cytokines are predominantly produced by T helper cells ( T h ) and macrophages and involved in the upregulation of inflammatory reactions. [ 1 ]
They act by inhibiting gene expression of cytokines including Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha by binding to corticosteroid response elements on DNA. [1] This decrease in cytokine production reduces T cell proliferation. With decreased T cell proliferation there is decreased production of IL-2.
Anti-interleukin-6 agents are a class of therapeutics.Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. [1] Hence, anti-IL6 agents have been sought.
Cardiac arrest, cytokine release syndrome, tumor lysis syndrome and acute kidney injury, infections, [14] hepatitis B reactivation, immune toxicity, pulmonary toxicity, [15] bowel obstruction and perforation [16] [17] [18] Trastuzumab (Herceptin) A monoclonal antibody against HER2/neu (erb-B2). Helps kill breast cancer cells that overexpress ...
This is a list of chemotherapeutic agents, also known as cytotoxic agents or cytostatic drugs, that are known to be of use in chemotherapy for cancer.This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision.
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