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Alanine transaminase (ALT), also known as alanine aminotransferase (ALT or ALAT), formerly serum glutamate-pyruvate transaminase (GPT) or serum glutamic-pyruvic transaminase (SGPT), is a transaminase enzyme (EC 2.6.1.2) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. [1]
Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.
The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.
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GPT-4o mini is the default model for users not logged in who use ChatGPT as guests and those who have hit the limit for GPT-4o. GPT-4o mini will become available in fall 2024 on Apple's mobile devices and Mac desktops, through the Apple Intelligence feature.
GPT-1 achieved a 5.8% and 1.5% improvement over previous best results [3] on natural language inference (also known as textual entailment) tasks, evaluating the ability to interpret pairs of sentences from various datasets and classify the relationship between them as "entailment", "contradiction" or "neutral". [3]
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