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Two of the genetic disorders that may affect spinal tumors, include Von Hippel-Lindau disease and Neurofibromatosis 2. Von Hippel-Lindau disease is a non-cancerous tumor of blood vessels that occur in the brain, spinal cord, or even tumors in the kidneys. The Neurofibromatosis 2 is a non-cancerous tumor that usually affects the nerves for hearing.
Degenerative spinal disorders involve a loss of function in the spine. Pressure on the spinal cord and nerves may be associated with herniation or disc displacement. Brain degeneration also causes central nervous system diseases (i.e. Alzheimer's, Lewy body dementia, Parkinson's, and Huntington's diseases).
Occipito-cervical junction This disorder may result from rheumatoid arthritis, causing the hypermobility of the connection between the neck and head, resulting in paralysis or pain. [6] Cerebrovascular disease Cerebrovascular disease is a type of cervical spine disorder that can cause tetraplegia. [7] Subaxial cervical spine [8] Atlanto-axial joint
Atopy: an immune disorder of children manifesting as eczema or other allergic conditions. [5] It can include atopic myelitis, which causes weakness. [6] Immune-mediated myelopathies, heterogeneous group of inflammatory spinal cord disorders including autoimmune disorders with known antibodies [7]
Tethered spinal cord can be caused by various conditions but the main cause is when tissue attachments limit the movement of the spinal cord in the spinal column which causes abnormal stretching of the cord. The tethered spinal cord syndrome is correlated with having the causes: [10] Spina bifida. Occulta; Mylomeningocele; Meningocele
When systemic blood pressure drops, blood flow to the spinal cord may be reduced, potentially causing a loss of sensation and voluntary movement in the areas supplied by the affected level of the spinal cord. [85] Congenital conditions and tumors that compress the cord can also cause SCI, as can vertebral spondylosis and ischemia. [5]
Spinal stenosis is an abnormal narrowing of the spinal canal or neural foramen that results in pressure on the spinal cord or nerve roots. [6] Symptoms may include pain, numbness, or weakness in the arms or legs. [1] Symptoms are typically gradual in onset and improve with leaning forward. [1]
Vascular myelopathy (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood supply. [1] The blood supply is complicated and supplied by two major vessel groups: the posterior spinal arteries and the anterior spinal arteries—of which the Artery of Adamkiewicz is the largest. [2]