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The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s, and the most fundamental definitions underlying the phenomenon were drafted by this time. [by whom?] The most important aspects in quality control of chemotaxis assays were described by H. Harris in the 1950s. [12]
In general terms, chemotaxis is a biological process where living entities, such as cells or organisms, detect, maneuver, and react in response to a chemical signal in their environment. [1] Such a phenomenon is critical for many biological processes, including but not limited to wound healing, detection of food, and avoidance of many toxins. [2]
Other chemotaxis assay techniques Besides the above-mentioned two most commonly used family of techniques, a wide range of protocols were developed to measure chemotactic activity. Some of them are only qualitative, like aggregation tests, where small pieces of agar or filters are placed onto a slide and accumulation of cells around is measured.
Of the two directional varieties of chemotaxis, chemoattraction has been studied to a much greater extent. Only recently have the key components of the chemorepulsive pathway been elucidated. [ 1 ] The exact mechanism is still being investigated, and its constituents are currently being explored as likely candidates for immunotherapies.
Recent results proved that chemokines (e.g. IL-8, RANTES) are working on long-term chemotaxis receptors, while vasoactive peptides (e.g. endothelin) act more on the short-term ones. Term chemotactic selection is also used to design a technique which separates eukaryotic or prokaryotic cells upon their chemotactic responsiveness to selector ligands.
Since the discovery of sperm attraction to the female gametes in ferns over a century ago, [1] sperm guidance in the form of sperm chemotaxis has been established in a large variety of species [2] Although sperm chemotaxis is prevalent throughout the Metazoa kingdom, from marine species with external fertilization such as sea urchins and corals, to humans, [2] [3] [4] much of the current ...
Since the discovery of sperm attraction to the female gametes in ferns over a century ago, [1] sperm guidance in the form of sperm chemotaxis has been established in a large variety of species [2] Although sperm chemotaxis is prevalent throughout the Metazoa kingdom, from marine species with external fertilization such as sea urchins and corals, to humans, [2] [3] [4] much of the current ...
6361 20295 Ensembl ENSG00000102970 ENSMUSG00000031780 UniProt Q92583 n/a RefSeq (mRNA) NM_002987 NM_011332 RefSeq (protein) NP_002978 n/a Location (UCSC) Chr 16: 57.4 – 57.42 Mb Chr 8: 95.54 – 95.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes ...