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The globus pallidus receives input from the striatum and sends inhibitory output to a number of motor-related areas. The substantia nigra is the source of the striatal input of the neurotransmitter dopamine, which plays an important role in basal ganglia function. The subthalamic nucleus mainly receives input from the striatum and cerebral ...
It is part of the basal ganglia, which, among many other functions, regulate movements that occur on the subconscious level. The globus pallidus has a predominantly inhibitory effect on movement regulation, balancing cerebellar excitation. Pulsatile and regular interaction between these complementary systems allows smooth and controlled movement.
As the GPi is one of the direct output centers of the basal ganglia, this causes disinhibition of the thalamus, increasing overall ease of initiating and maintaining movement. As this pathway only contains one synapse (from the striatum to the internal globus pallidus), it is known as the direct pathway .
It also involves another basal ganglia component the substantia nigra, a part of the midbrain. [2] In a resting individual, a specific region of the globus pallidus, the internal globus pallidus (GPi), and a part of the substantia nigra, the pars reticulata (SNpr), send spontaneous inhibitory signals to the ventral lateral nucleus (VL) of the ...
The function of the STN is not fully understood but it is believed that, as a component of the basal ganglia, it plays a part in the so-called "hyperdirect" and "indirect" pathways of motor control, as opposed to the direct pathway which bypasses the STN on its way from the Striatum to the internal pallidum.
The basal ganglia is a collective group of structures in the brain. These include the striatum, (composed of the putamen and caudate nucleus), globus pallidus, substantia nigra, and the subthalamic nucleus. Along with other structures, the basal ganglia are part of a neural circuit that is integral to voluntary motor function. [1]
The basal ganglia are located bilaterally, and have rostral and caudal divisions. The putamen is located in the rostral division as part of the striatum. The basal ganglia receive input from the cerebral cortex, via the striatum. This is a transverse section of the striatum from a structural MR image.
The basal ganglia functions to tonically inhibit movement, mainly in the absence of motor cortex command, via GABAergic inhibition of the ventral lateral nucleus and ventral anterior nucleus of the thalamus, as well as the superior colliculus and mesopontine tegmentum of the brain stem.