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A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
Chondroitin sulfate; Dermatan sulfate; Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis. [2] In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine ...
Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. [citation needed] Glucosamine, along with commonly used chondroitin, is not routinely prescribed to treat people who have symptomatic osteoarthritis of the knee, as there is insufficient evidence that this treatment is helpful ...
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One of the main functions of the third class of GAGs, keratan sulfates, is the maintenance of tissue hydration. [18] Keratan sulfates are in the bone, cartilage, and the cornea of the eye. [ 19 ] Within the normal cornea, dermatan sulfate is fully hydrated whereas keratan sulfate is only partially hydrated suggesting that keratan sulfate may ...
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