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For many biologics (e.g., monoclonal antibodies), injection site reactions are the most common adverse effect of the drug, and have been reported to have an incidence rate of 0.5–40%. [ 2 ] In trials of subcutaneous administration of oligonucleotides , between 22 and 100% of subjects developed reactions depending on the oligonucleotide.
Intramuscular injections commonly result in pain, redness, and swelling or inflammation around the injection site. These side effects are generally mild and last no more than a few days at most. Rarely, nerves or blood vessels around the injection site can be damaged, resulting in severe pain or paralysis.
One of the most common side effects of subcutaneous administration is moderate to severe pain at the injection site. [10] Although the manufacturer recommends keeping maropitant at room temperature, many people have noted that keeping it in the fridge reduces the sting upon injection.
Semaglutide injection side effects — like skin irritation — can also occur at the injection site. ... and abdominal pain by using over-the-counter medications during the adjustment period ...
Overall, side effects from a half-strength third dose of Moderna's vaccine were similar to a second dose. Younger people recorded more side effects.
The most common adverse effects of intercavernosal injections include fibrosis and pain, as well as hematomas or bruising around the injection site. [ 20 ] Medications may also be administered by injecting them directly into the vitreous humor of the eye.
One of propofol's most common side effects is pain on injection, especially in smaller veins. This pain arises from activation of the pain receptor, TRPA1, [54] found on sensory nerves and can be mitigated by pretreatment with lidocaine. [55] Less pain is experienced when infused at a slower rate in a large vein (antecubital fossa).
Even though the pain can be debilitating, Dr. Birnbaum warns against using opioids to manage it. “In most cases, the use of opioid medications should not be the first-line medication used.