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Multiple epiphyseal dysplasia (MED), also known as Fairbank's disease, is a rare genetic disorder (dominant form: 1 in 10,000 births) that affects the growing ends of bones. Long bones normally elongate by expansion of cartilage in the growth plate (epiphyseal plate) near their ends.
Hypothermia is defined as a body core temperature below 35.0 °C (95.0 °F) in humans. [2] Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion.
Those affected are unable to feel pain and temperature. [2] [3] The absence of pain experienced by people with CIPA puts them at high risk for accidental self-injury. Corneal ulceration occurs due to a lack of protective impulses. [4] Joint and bone problems are common due to repeated injuries, and wounds heal poorly. [5]
Grade 3: if there is a lesion on the intermediate or near body part, auto-amputation and loss of function can occur Grade 4: if there is a lesion very near the body (such as the carpals of the hand), the limb can be lost. Sepsis and/or other systemic problems are expected. [7] A number of long term sequelae can occur after frostbite.
The spine shows platyspondyly, the cranium has a short base, and, frequently, the foramen magnum is decreased in size. The forehead is prominent, and hypertelorism and a saddle nose may be present. Hands and feet are normal, but fingers are short. Type II is characterized by short, straight long bones and cloverleaf skull. [1]
An individual's body temperature typically changes by about 0.5 °C (0.9 °F) between its highest and lowest points each day. [15] Body temperature is sensitive to many hormones, so women have a temperature rhythm that varies with the menstrual cycle, called a circamensal rhythm. [11] [unreliable medical source?
The articular surfaces of short bones are covered with hyaline cartilage, similar to long bones. The outer surface of the bone, except for the articular surfaces, is covered by the periosteum. [6] Short bones have no clear diaphysis (bone shaft) and metaphysis and have poor vascular supply. [1] [2] Section through the human wrist showing the ...
The long, relatively straight main body of a long bone; region of primary ossification. Also known as the shaft. dia-+ physis, "between the growth parts" epiphysis: The end regions of a long bone; regions of secondary ossification. epi-+ physis, "on top of the growth part" physis (epiphyseal plate) Also known as the growth plate.