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Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
Upon the inactivation of PTCH1 by Shh, glioma-associated (GLI) transcription factors enter the nucleus and activate the expression of multiple genes including Myc, Bcl-2, NANOG, and SOX2. Targets of GLIs include genes involved in cell proliferation, apoptosis , angiogenesis , epithelial-mesenchymal transition , and self-renewal of stem cells .
C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. [5] Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major regulator of the contact system (PK, FXIIa, and FXIa).
WNT1-inducible-signaling pathway protein 1 (WISP-1), [5] is a member of the CCN protein family and should correctly be referred to as CCN4 as suggested by the International CCN Society. [6] It is a matricellular protein that in humans is encoded by the WISP1 gene .
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is ...
1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12: 12.69 – 12.72 Mb Chr 6: 134.9 – 134.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It ...
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
Studies show that O-GlcNAc transferase interacts directly with the Ten eleven translocation 2 enzyme, which converts 5-methylcytosine to 5-hydroxymethylcytosine and regulates gene transcription. [32] Additionally, increasing levels of OGT for O -GlcNAcylation may have therapeutic effects for Alzheimer's disease patients.