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The first protein to be classified as a suppressor of cytokine signaling, CIS (cytokine-inducible SH2), was discovered in 1995, when it was found to have a unique ability to regulate cytokine signal transduction. [2]
The structures of human P-TEFb containing Cdk9 and cyclin T1 and the HIV Tat•P-TEFb complex have been solved using X-ray crystallography. The first structure solved demonstrated that the two subunits were arranged as has been found in other cyclin dependent kinases. [ 19 ]
Upon the inactivation of PTCH1 by Shh, glioma-associated (GLI) transcription factors enter the nucleus and activate the expression of multiple genes including Myc, Bcl-2, NANOG, and SOX2. Targets of GLIs include genes involved in cell proliferation, apoptosis , angiogenesis , epithelial-mesenchymal transition , and self-renewal of stem cells .
Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
54206 74155 Ensembl ENSG00000116285 ENSMUSG00000028967 UniProt Q9UJM3 Q99JZ7 RefSeq (mRNA) NM_018948 NM_133753 NM_001356323 RefSeq (protein) NP_061821 NP_598514 NP_001343252 Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.94 – 150.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is ...
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12: 12.69 – 12.72 Mb Chr 6: 134.9 – 134.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It ...
WNT1-inducible-signaling pathway protein 1 (WISP-1), [5] is a member of the CCN protein family and should correctly be referred to as CCN4 as suggested by the International CCN Society. [6] It is a matricellular protein that in humans is encoded by the WISP1 gene .