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Von Hippel–Lindau disease is inherited in an autosomal dominant pattern. Every cell in the body has two copies of every gene (bar those found in the sex chromosomes, X and Y). In VHL disease, one copy of the VHL gene has a mutation and produces a faulty VHL protein (pVHL).
Von Hippel–Lindau syndrome (VHL) is a dominantly inherited hereditary cancer syndrome predisposing to a variety of malignant and benign tumors of the eye, brain, spinal cord, kidney, pancreas, and adrenal glands. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. Individuals with VHL syndrome inherit one ...
Based on the anatomic site, it is difficult to completely remove, and so while there is a good prognosis, recurrences or persistence may be seen. There is no metastatic potential. Patients who succumb to the disease, usually do so because of other tumors within the von Hippel-Lindau complex rather than from this tumor.
This condition is known today as Von Hippel–Lindau disease (VHL). Hippel contributed several writings to textbooks regarding anatomy and diseases of the eye. He was the son of Arthur von Hippel (1841–1916), a pioneer in corneal transplantation, and an uncle to German-American physicist Arthur R. von Hippel (1898–2003).
Prefoldin subunit 3 (VBP-1), [1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. [2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post ...
Arthur Robert von Hippel (November 19, 1898 – December 31, 2003) [1] was a German American materials scientist and physicist. Von Hippel was a pioneer in the study of dielectrics , ferromagnetic and ferroelectric materials, and semiconductors and was a codeveloper of radar during World War II.
Eric von Hippel (born 1941), an American economist, son of Arthur R. von Hippel; Frank N. von Hippel, an American nuclear physicist, son of Arthur R. von Hippel; Eugen von Hippel (1867–1939), a German ophthalmologist, his son (discoverer of Von Hippel–Lindau disease) Karin von Hippel; Theodor Gottlieb von Hippel the Elder (1741–1796), a ...
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