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Muir–Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome [1]: 663 that is thought to be a subtype of HNPCC (Lynch syndrome). Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors .
Sebaceous adenomas, in isolation, are not significant; however, they may be associated with Muir-Torre syndrome, a genetic condition that predisposes individuals to cancer. [3] It is also linked to hereditary nonpolyposis colorectal cancer (Lynch syndrome). [citation needed]
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
Other SGc including those occurring outside of the head and neck region and the presentation of multiple at a time are believed to be associated with genetic defects including defects in mismatch repair genes, Muir–Torre syndrome (MTS), and familial retinoblastoma. [11] [10] [9]
Seboacanthoma is a cutaneous condition, and a specific type of sebaceous adenoma which may be specific to Muir–Torre syndrome. [1] See also. Sebaceous nevus syndrome;
Sebaceous adenoma, a benign slow-growing tumour—which may, however, in rare cases be a precursor to a cancer syndrome known as Muir–Torre syndrome. [5] Sebaceous carcinoma, an uncommon and aggressive cutaneous tumour. [37]
Yellow Veil Pictures and Vinegar Syndrome announced have co-acquired North American rights for “Riddle of Fire,” the feature debut of writer and director Weston Razooli. The movie follows ...
MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors in Lynch syndrome are caused by germline mutations in MLH1, MSH2, MSH6, and PMS2. [3] MSI has been evident in the cause of sebaceous carcinomas. Sebaceous carcinomas are a subset of a larger pathology, Muir-Torre ...