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Muir–Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome [1]: 663 that is thought to be a subtype of HNPCC (Lynch syndrome). Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors .
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
Other SGc including those occurring outside of the head and neck region and the presentation of multiple at a time are believed to be associated with genetic defects including defects in mismatch repair genes, Muir–Torre syndrome (MTS), and familial retinoblastoma. [11] [10] [9]
Sebaceoma is a smooth-bordered, plump, well-circumscribed benign tumor that may expand into the subcutis, middle dermis, and deep dermis. Lesions range in size from tiny lesions to 20 mm. Clinically, the tumor appears as a single flesh-colored or erythematous nodule or plaque in the head and neck region.
Muir–Torre syndrome; Multiple familial trichoepithelioma (Brooke–Spiegler syndrome, epithelioma adenoides cysticum) Multiple keratoacanthomas (Ferguson–Smith syndrome, Ferguson-Smith type of multiple self-healing keratoacanthomas, multiple keratoacanthomas of the Ferguson–Smith type)
Sebaceous adenoma, a benign slow-growing tumour—which may, however, in rare cases be a precursor to a cancer syndrome known as Muir–Torre syndrome. [5] Sebaceous carcinoma, an uncommon and aggressive cutaneous tumour. [37]
The Yankees allowed Torre, who won four World Series titles during his tenure in the Bronx, to come out from the dugout and take out starter Carlos Rodon following Rodon's 5 2/3 innings of no-hit ...
Mismatch repair cancer syndrome (MMRCS) is a cancer syndrome associated with biallelic DNA mismatch repair mutations. [1] It is also known as Turcot syndrome (after Jacques Turcot, who described the condition in 1959) and by several other names. [1] In MMRCS, neoplasia typically occurs in both the gut and the central nervous system (CNS). [1]