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The conclusions for progesterone were the same in a 2019 meta-analysis of the worldwide epidemiological evidence by the Collaborative Group on Hormonal Factors in Breast Cancer (CGHFBC). [131] Most data on breast density changes and breast cancer risk are with oral progesterone. [126] Data on breast safety with vaginal progesterone are scarce ...
The increase in breast cancer risk with estrogen and progestogen therapy was shown to be causal with conjugated estrogens plus medroxyprogesterone acetate in the Women's Health Initiative randomized controlled trials. [122] [155] Breast cancer risk with combined estrogen and progestogen therapy may differ depending on the progestogen used.
Progesterone also appears to be involved in the pathophysiology of breast cancer, though its role, and whether it is a promoter or inhibitor of breast cancer risk, has not been fully elucidated.
Researchers from the Danish Cancer Society Research Center have found an association between levonorgestrel-releasing intrauterine systems (LNG-IUSs) and increased breast cancer risk in females ...
As for the notion that certain types of HRT might increase the risk of breast cancer, Dr. Nichols says there’s no strong clinical evidence linking hormone replacement therapy to increased cancer ...
Therapy can take the form of an estrogen pill, skin patch, ring, gel, cream, or spray, and it usually includes a second hormone, progestogen, which can be either progesterone or a synthetic progestin.
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