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  2. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    Critically short telomeres trigger a DNA damage response and cellular senescence. [32] Mice have much longer telomeres, but a greatly accelerated telomere shortening-rate and greatly reduced lifespan compared to humans and elephants. [33] Telomere shortening is associated with aging, mortality, and aging-related diseases in experimental animals.

  3. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres. [2]

  4. Chromosome 2 - Wikipedia

    en.wikipedia.org/wiki/Chromosome_2

    Chromosome 2 is one of the twenty-three pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 2 is the second-largest human chromosome, spanning more than 242 million base pairs [4] and representing almost eight percent of the total DNA in human cells. Chromosome 2 contains the HOXD homeobox gene cluster ...

  5. Breakage-fusion-bridge cycle - Wikipedia

    en.wikipedia.org/wiki/Breakage-fusion-bridge_cycle

    This results in the two daughter cells receiving an uneven chromatid. [4] Since the two resulting chromatids lack telomeres, when they replicate the BFB cycle will repeat, and will continue every subsequent cell division until those chromatids receive a telomere, usually from a different chromatid through the process of translocation. [4]

  6. Shelterin - Wikipedia

    en.wikipedia.org/wiki/Shelterin

    Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate telomerase activity. In mammals and other vertebrates, telomeric DNA consists of repeating double-stranded 5'-TTAGGG-3' (G-strand) sequences (2-15 kilobases in humans) along with the 3'-AATCCC-5' (C-strand) complement, ending with a 50-400 ...

  7. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Telomeres at the end of a chromosome. The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan and even human immortality. [1] [2] Telomeres are sequences at the ends of chromosomes that shorten with each cell division and determine the lifespan of ...

  8. Today’s NYT ‘Strands’ Hints, Spangram and Answers for ...

    www.aol.com/today-nyt-strands-hints-spangram...

    The spangram describes the puzzle’s theme and touches two opposite sides of the board. It may be two words. ... Related: 15 Fun Games Like Connections to Play Every Day. Show comments ...

  9. Subtelomere - Wikipedia

    en.wikipedia.org/wiki/Subtelomere

    Telomeres are specialized protein–DNA constructs present at the ends of eukaryotic chromosomes, which prevent them from degradation and end-to-end chromosomal fusion. Most vertebrate telomeric DNA consists of long (T T A G G G)n repeats of variable length, often around 3-20kb. Subtelomeres are segments of DNA between telomeric caps and ...