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[11] [a] Dementia ultimately has a significant effect on the individual, their caregivers, and their social relationships in general. [2] A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than might be caused by the normal aging process. [13]
Dementia can be categorized as reversible (e.g. thyroid disease) or irreversible (e.g. Alzheimer's disease). [12] Currently, there are more than 35 million people with dementia worldwide. In the United States alone the number of people affected by dementia is striking at 3.8 million. [13]
Between 40% and 80% of people with Alzheimer's disease possess at least one APOEε4 allele. [63] The APOEε4 allele increases the risk of the disease by three times in heterozygotes and by 15 times in homozygotes. [64] Like many human diseases, environmental effects and genetic modifiers result in incomplete penetrance.
Pre-dementia or early-stage dementia (stages 1, 2, and 3). In this initial phase, a person can still live independently and may not exhibit obvious memory loss or have any difficulty completing ...
Alzheimer's disease is the most common cause of dementia and results in a continuous decline of cognition, social skills, and behavior. Alzheimer's is associated in part with age, and is much more ...
For the study, which was published in February in the Annals of Neurology, researchers recruited 231 healthy older people without dementia or mild cognitive impairment (which is considered a ...
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