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Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
Absorptive cells in the small intestine are known as enterocytes, and in the colon they are known as colonocytes. The other cell types are the secretory cells – goblet cells, Paneth cells, enteroendocrine cells, and Tuft cells. Paneth cells are absent in the colon. [1] [2]
Intestinal glands of the small intestine contain a base of replicating stem cells, Paneth cells of the innate immune system, and goblet cells, which produce mucus. [1] In the colon, crypts do not have Paneth cells.
Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells: 21081128 [13] 19386267 [14] 8552090 [15] CTNNB1: Catenin, beta: Paneth cell differentiation. Essential for stem ...
In the colon, epithelium is simple columnar and without villi. Goblet cells, which secrete mucus, are also present. [1] The appendix has a mucosa resembling the colon but is heavily infiltrated with lymphocytes.
Mucus forms a layer (or layers, in the case of the colon) that separates the bulk of the luminal contents from the intestinal epithelium. The mucus consists of a highly glycosylated hydrated gel formed by mucin molecules that are secreted by goblet cells. The mucus prevents large particles from contacting the epithelial cell layer while ...
Most hyperplastic polyps are found in the distal colon and rectum. [2] They have no malignant potential, [2] ... They are filled with goblet cells, extending to ...
Intestinal stem cell aging has been studied in Drosophila as a model for understanding the biology of stem cell/niche aging. [4] Using knockdown mutants defective in various genes that function in the DNA damage response in enterocytes, it was shown that deficiency in the DNA damage response accelerates intestinal stem cell aging, thus ...