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A contingent convertible bond (CoCo), also known as an enhanced capital note (ECN), [1] is a fixed-income instrument that is convertible into equity if a pre-specified trigger event occurs. [2] The concept of CoCo has been particularly discussed in the context of crisis management in the banking industry. [ 3 ]
An acidic group like tetrazole, CO 2 H or NHSO 2 CF 3 at the 1-position of the biphenyl-methyl group will bind to a basic position in the receptor and are required for potent antagonistic activity. [19] In valsartan, the imidazole ring of losartan has been replaced with an acylated amino acid. [4]
Angiotensin II receptor type 1 (AT1) is a G q/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system.
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
As part of the deal, CHF 16 billion ($17.2 billion) of Additional Tier 1 bonds (AT1) were written down to zero on FINMA's authorization – the largest writedown of AT1 debt so far. The move forced larger losses on bondholders than on shareholders of Credit Suisse, [ 5 ] [ 34 ] and was done to placate the international investors unable to vote ...
AT1 may refer to: Angiotensin II receptor type 1; Additional Tier 1 capital, see Contingent convertible bond; Yamaha AT1 (1969-1971) motorcycle; Ekspress AT1, communications satellite AT1 in the Ekspress network; AeroTech Release 1; tabletop wargame
The term agostic is reserved to describe two-electron, three-center bonding interactions between carbon, hydrogen, and a metal. Two-electron three-center bonding is clearly implicated in the complexation of H 2, e.g., in W(CO) 3 (PCy 3) 2 H 2, which is closely related to the agostic complex shown in the figure. [8]
On the molecular level, the interlocked molecules cannot be separated without the breaking of the covalent bonds that comprise the conjoined molecules; this is referred to as a mechanical bond. Examples of mechanically interlocked molecular architectures include catenanes , rotaxanes , molecular knots , and molecular Borromean rings .