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Lipid flippase MsbA Molybdate transporter AB 2 C 2 complex, open state. The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families. It is represented in all extant phyla, from prokaryotes to humans.
1244 12780 Ensembl ENSG00000023839 ENSMUSG00000025194 UniProt Q92887 Q8VI47 RefSeq (mRNA) NM_000392 NM_013806 RefSeq (protein) NP_000383 NP_038834 Location (UCSC) Chr 10: 99.78 – 99.85 Mb Chr 19: 43.77 – 43.83 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT ...
A more general transmembrane transporter classification can be found in TCDB database. ... such as ABC (ATP Binding Cassette ... subfamily 2 (SLCO2A1, SLCO2B1 ...
The transporter has been shown to play protective roles in blocking absorption at the apical membrane of the intestine, and at the blood–testis barrier, [10] the blood–brain barrier, [10] and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics.
ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle.
The American Broadcasting Company (ABC) is a commercial broadcasting television network owned by Disney Entertainment, a subsidiary of The Walt Disney Company. Headquartered on Columbus Avenue and West 66th Street in Manhattan, ABC is the fifth-oldest major broadcasting network in the world. The network began its TV operations in 1948.
ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family ( Pfam PF00005 ) have two such regions.
ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene. [5] [6] ABCC8 orthologs [7] have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.