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2. Sickle cell disease - Wikipedia

   en.wikipedia.org/wiki/Sickle_cell_disease

   Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]

3. Sickle cell trait - Wikipedia

   en.wikipedia.org/wiki/Sickle_cell_trait

   The sickle cell trait provides a survival advantage against malaria fatality over people with normal hemoglobin in regions where malaria is endemic. The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism.

4. Missense mutation - Wikipedia

   en.wikipedia.org/wiki/Missense_mutation

   In the most common variant of sickle-cell disease, the 20th nucleotide of the gene for the beta chain of hemoglobin is altered from the codon GAG to GTG. Thus, the 6th amino acid glutamic acid is substituted by valine—notated as an "E6V" mutation—and the protein is sufficiently altered to cause the sickle-cell disease. [5]

5. U.S. approves two sickle cell gene therapies, which doctors ...

   www.aol.com/news/u-approves-two-sickle-cell...

   The two gene therapies are the first approved in the U.S. for sickle cell disease. The FDA has previously OK’d 15 gene therapies for other conditions. In the U.S., an estimated 100,000 people ...

6. FDA considers first CRISPR gene editing treatment that may ...

   www.aol.com/fda-considers-first-crispr-gene...

   Sickle cell is rare, and it disproportionately impacts African Americans. About 100,000 people in the US are diagnosed with sickle cell and, of those, 20,000 have what’s considered severe disease.

7. Why gene therapy for sickle cell is slow to catch on with ...

   www.aol.com/news/why-gene-therapy-sickle-cell...

   Student Zoe Davis, 20, was just weeks into her junior year when she landed back in the hospital with severe sickle cell pain earlier this month. She knows new gene therapies may provide long-term ...