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This results in an increase in the calcium concentration, which triggers the exocytosis of neurotransmitter vesicles at ribbon synapses at the basolateral surface of the hair cell. The release of neurotransmitter at a ribbon synapse, in turn, generates an action potential in the connected auditory-nerve fiber. [7]
Neurons whose cell bodies lie in the spiral ganglion are strung along the bony core of the cochlea, and send fibers into the central nervous system (CNS). These bipolar neurons are the first neurons in the auditory system to fire an action potential, and supply all of the brain's auditory input.
The olivocochlear system is a component of the auditory system involved with the descending control of the cochlea.Its nerve fibres, the olivocochlear bundle (OCB), form part of the vestibulocochlear nerve (VIIIth cranial nerve, also known as the auditory-vestibular nerve), and project from the superior olivary complex in the brainstem to the cochlea.
The cochlear nerve (also auditory nerve or acoustic nerve) is one of two parts of the vestibulocochlear nerve, a cranial nerve present in amniotes, the other part being the vestibular nerve. The cochlear nerve carries auditory sensory information from the cochlea of the inner ear directly to the brain. The other portion of the vestibulocochlear ...
In mammalian outer hair cells, the varying receptor potential is converted to active vibrations of the cell body. This mechanical response to electrical signals is termed somatic electromotility; [13] it drives variations in the cell's length, synchronized to the incoming sound signal, and provides mechanical amplification by feedback to the traveling wave.
There are two types of hair cells specific to the auditory system; inner and outer hair cells. Inner hair cells are the mechanoreceptors for hearing: they transduce the vibration of sound into electrical activity in nerve fibers, which is transmitted to the brain. Outer hair cells are a motor structure.
The pyramidal cells or giant cells are a major cell grouping of the DCN. These cells are the target of two different input systems. The first system arises from the auditory nerve, and carries acoustic information. The second set of inputs is relayed through a set of small granule cells in the cochlear nucleus.
K v 1.1 and K v 1.2 are located in the transition zone between the axon and the terminal, while K v 1.3 K v 7.5 are located in the calyx. [15] There is a calcium activated potassium channel expressed in the calyx, however this type of channel does not contribute to neurotransmitter release.