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Cerebral edema is a potentially life-threatening complication of severely decreased sodium ion concentration in the blood (hyponatremia). [17] Ionic brain edema can also occur around the sites of brain hemorrhages, infarcts, or contusions due to a local plasma osmolality pressure gradient when compared to the high osmolality in the affected tissue.
Instead, it is most commonly associated with hemorrhage of small vessels in the cerebral cortex. [2] The strongest risk factor for intraparenchymal hemorrhage associated with cerebral amyloid angiopathy is old age, and cerebral amyloid angiopathy is most frequently seen in patients who already have, or will soon be diagnosed with, dementia. [3]
These factors cause the brain to swell with fluid, resulting in severe impairment. [15] If the swelling is untreated, it causes death by brain herniation. [4] The brain swelling is likely a result of vasogenic edema, the penetration of the blood–brain barrier by fluids. [16] This process has been observed in MRI studies.
Cerebral edema is mainly classified into cytotoxic edema, vasogenic edema and interstitial edema. Cytotoxic edema affects both the white and gray matter and results from the swelling of cellular elements such as neurons, glia and endothelial cells. Vasogenic edema affects white matter and results from blood brain barrier (BBB) breakdown ...
Vasodilatory shock, vasogenic shock, or vasoplegic shock is a medical emergency belonging to shock along with cardiogenic shock, septic shock, allergen-induced shock and hypovolemic shock. When the blood vessels suddenly relax, it results in vasodilation .
The "vasogenic" theory posits that elevated blood pressure overcomes the normal capability of blood vessels in the brain to maintain a normal cerebral blood flow. The excessive pressure damages the endothelial layer and the blood–brain barrier, leading to swelling (edema).
Lee's death was officially ruled the result of cerebral edema — swelling of the brain. While a normal human brain is about 3 pounds, Lee's was reportedly closer to 3½ pounds.
The ischemic (ischaemic) cascade is a series of biochemical reactions that are initiated in the brain and other aerobic tissues after seconds to minutes of ischemia (inadequate blood supply). [1] This is typically secondary to stroke , injury, or cardiac arrest due to heart attack .