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Between 1998 and 2007, 33 serious adverse drug or device reactions have been reported by RADAR investigators. The toxicities involved multiple biological system and included thrombotic thrombocytopenic purpura (TTP) (ticlopidine and clopidogrel), thromboembolism (thalidomide and lenalidomide), liver failure (gemtuzumab and nevirapine), hypersensitivity (drug eluting coronary arterial stents ...
Drug use disorder: A variety of drugs and drug paraphernalia: Specialty: Psychiatry, clinical psychology: Symptoms: Excessive use of drugs despite adverse consequences: Complications: Drug overdose; [1] general negative long-term effects on mental and physical health; acquiring infectious diseases; [2] in some cases criminal behaviour [3] Risk ...
In drug development, serious adverse event (SAE) is defined as any untoward medical occurrence during a human drug trial that at any dose Results in death; Is life-threatening; Requires inpatient hospitalization or causes prolongation of existing hospitalization; Results in persistent or significant disability/incapacity
The severity can be classified as mild, moderate, or severe based on the number of criteria present. [6] The tolerance and withdrawal criteria are not considered to be met for individuals taking opioids solely under appropriate medical supervision. [4] Addiction and dependence are components of a substance use disorder; addiction is the more ...
At high doses, prescription amphetamines, used to treat ADHD could increase a person’s risk of psychosis. Image credit: visualspace/Getty Images.
Substance-induced psychosis (commonly known as toxic psychosis or drug-induced psychosis) is a form of psychosis that is attributed to substance intoxication, withdrawal or recent consumption of psychoactive drugs. It is a psychosis that results from the effects of various substances, such as medicinal and nonmedicinal substances, legal and ...
A new study suggests that GLP-1 agonist medications like Ozempic, which are used for diabetes management and weight loss, may help reduce the risk of overdose and alcohol intoxication in people ...
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.