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Acute megakaryoblastic leukemia (AMKL) is life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Megakaryoblasts are the most immature precursor cells in a platelet-forming lineage; they mature to promegakaryocytes and, ultimately, megakaryocytes which cells shed membrane-enclosed particles, i.e. platelets, into the circulation.
Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2] The megakaryoblast resembles the myeloblast or lymphoblast morphologically; however the megakaryoblast varies in phenotype and the structure viewed with electron microscopy.
Acute megakaryoblastic leukemia: A life-threatening leukemia in which malignant megakaryoblasts proliferate abnormally and injure various tissues. Blastic plasmacytoid dendritic cell neoplasm : A rare hematologic malignancy which is a malignancy of plasmacytoid dendritic cells .
The protein encoded by this gene is regulated by the actin cytoskeleton and is shuttled between the cytoplasm and the nucleus as a result of actin dynamics. [9] In the nucleus, it coactivates the transcription factor serum response factor, [10] a key regulator of smooth muscle cell differentiation, in an interaction mediated by its Basic domain.
A list of 'effects' that have been noticed in the field of psychology. [clarification needed] Ambiguity effect;
Acute lymphoblastic leukemia (ALL) 4.0% Acute myeloid leukemia (AML) 8.7% Chronic lymphocytic leukemia (CLL) sorted under lymphomas according to current WHO classification; called small lymphocytic lymphoma (SLL) when leukemic cells are absent. 10.2% Chronic myelogenous leukemia (CML) 3.7% Acute monocytic leukemia (AMoL) 0.7% Other leukemias 3.1%
Example of platelets release in mature megakaryocytes. This footage shows the formation and spontaneous release of platelets (small round-shaped blood cells), imaged with a live-cell imaging microscope. Thrombopoietin (TPO) is a 353-amino acid protein encoded on chromosome 3p27.
CFU-GEMM gives rise to CFU-GM (leading to monoblasts and myeloblasts), CFU-Meg (leading to megakaryoblasts), and CFU-E (leading to proerythroblasts). The stem cell will follow a specific lineage depending on the presence of certain growth factors and cytokines. The GM-CSF and IL-3 both work together to stimulate production of all lines.