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  2. First pass effect - Wikipedia

    en.wikipedia.org/wiki/First_pass_effect

    First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.

  3. Alcoholic hepatitis - Wikipedia

    en.wikipedia.org/wiki/Alcoholic_hepatitis

    The ratio of aspartate aminotransferase to alanine aminotransferase is usually 2 or more. [13] In most cases, the liver enzymes do not exceed 500. A liver biopsy is not required for the diagnosis, however it can help confirm alcoholic hepatitis as the cause of the hepatitis if the diagnosis is unclear. [3] [14]

  4. Naproxen - Wikipedia

    en.wikipedia.org/wiki/Naproxen

    Naproxen's medical uses are related to its mechanism of action as an anti-inflammatory compound. [11] Naproxen is used to treat a variety of inflammatory conditions and symptoms that are due to excessive inflammation, such as pain and fever (naproxen has fever-reducing, or antipyretic, properties in addition to its anti-inflammatory activity). [11]

  5. Proteins produced and secreted by the liver - Wikipedia

    en.wikipedia.org/wiki/Proteins_produced_and...

    All plasma proteins except Gamma-globulins are synthesised in the liver. [1] Human serum albumin, osmolyte and carrier protein; α-fetoprotein, the fetal counterpart of serum albumin; Soluble plasma fibronectin, forming a blood clot that stops bleeding; C-reactive protein, opsonin on microbes, [2] acute phase protein; Various other globulins

  6. Enterohepatic circulation - Wikipedia

    en.wikipedia.org/wiki/Enterohepatic_circulation

    Bilirubin is conjugated with glucuronic acid in the liver by the enzyme glucuronyltransferase, making it soluble in water. Much of it goes into the bile and thus out into the small intestine. Although 20% of the secreted bilirubinoid bile is reabsorbed by the small intestine, [2] conjugated

  7. Prednisone - Wikipedia

    en.wikipedia.org/wiki/Prednisone

    Prednisone is absorbed in the gastrointestinal tract and has a half-life of 2–3 hours. [37] it has a volume of distribution of 0.4–1 L/kg. [39] The drug is cleared by hepatic metabolism using cytochrome P450 enzymes. Metabolites are excreted in the bile and urine. [39]

  8. Alcohol intolerance - Wikipedia

    en.wikipedia.org/wiki/Alcohol_intolerance

    Chronic alcohol use is known to lead to liver pathologies, that being alcoholic liver disease, which leads to further liver conditions like FLD or steatosis, which is a buildup of fat in the liver, and cirrhosis, a buildup of scar tissue in the liver tissue. [30] Because liver enzyme function is based on the relative function of liver cells ...

  9. Alcoholic liver disease - Wikipedia

    en.wikipedia.org/wiki/Alcoholic_liver_disease

    Risk factors known as of 2010 are: Quantity of alcohol taken: Consumption of 60–80 g per day (14 g is considered one standard drink in the US, e.g. 1 + 12 US fl oz or 44 mL hard liquor, 5 US fl oz or 150 mL wine, 12 US fl oz or 350 mL beer; drinking a six-pack of 5% ABV beer daily would be 84 g and just over the upper limit) for 20 years or more in men, or 20 g/day for women ...