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2. Graft-versus-host disease - Wikipedia

   en.wikipedia.org/wiki/Graft-versus-host_disease

   Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). The ...

3. Thymus transplantation - Wikipedia

   en.wikipedia.org/wiki/Thymus_transplantation

   Second, a thymus transplantation can cause a non-donor T cell-related GVHD because the recipients thymocytes would use the donor thymus cells as models when going through the negative selection to recognize self-antigens, and could therefore still mistake own structures in the rest of the body for being non-self. This is a rather indirect GVHD ...

4. Transfusion-associated graft-versus-host disease - Wikipedia

   en.wikipedia.org/wiki/Transfusion-associated...

   The incidence of TA-GvHD in immunocompromised patients receiving blood transfusions is estimated to be 0.1–1.0%, and mortality around 80–90%. Mortality is higher in TA-GvHD than in GvHD associated with bone marrow transplantation , where the engrafted lymphoid cells in the bone marrow are of donor origin (in autotransplant) and therefore ...

5. Severe combined immunodeficiency - Wikipedia

   en.wikipedia.org/wiki/Severe_combined...

   Haploidentical bone marrow transplants require the donor marrow to be depleted of all mature T cells to avoid the occurrence of graft-versus-host disease (GVHD). [16] Consequently, a functional immune system takes longer to develop in a patient who receives a haploidentical bone marrow transplant compared to a patient receiving a matched ...

6. Thymoma-associated multiorgan autoimmunity - Wikipedia

   en.wikipedia.org/wiki/Thymoma-associated_multi...

   Thymoma is a common neoplasm arising from the thymus, the primary lymphoid organ where T cells become educated to distinguish "self" from "non self". In the setting of thymoma, abnormal thymic education occurs as a result of subtle differences in antigen processing. In TAMA these differences result in autoreactive T cells escaping from the thymus.

7. Graft-versus-tumor effect - Wikipedia

   en.wikipedia.org/wiki/Graft-versus-tumor_effect

   This will occur with most of the non-related donor. When transplanting HSC during AML, T-cells are usually selectively depleted to prevent GvHD while NK cells help with the GvL effect which prevent leukemia relapse. When using non-depleted T-cell transplant, cyclophosphamide is used after transplantation to prevent GvHD or transplant rejection.