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Carbohydrate-binding module family 6 (CBM6) is unusual in that it contains two substrate-binding sites, cleft A and cleft B. Cellvibrio mixtus endoglucanase 5A contains two CBM6 domains, the CBM6 domain at the C-terminus displays distinct ligand binding specificities in each of the substrate-binding clefts.
Included in the database are families of glycoside hydrolases, [3] glycosyltransferases, [4] polysaccharide lyases, [5] carbohydrate esterases, [6] and non-catalytic carbohydrate-binding modules. [7] The CAZy database also includes a classification of Auxiliary Activity redox enzymes involved in the breakdown of lignocellulose. [8]
HexB is structurally similar to chitobiase, consisting of a beta sandwich structure; this structure is similar to that found in the cellulose-binding domain of cellulase from Cellulomonas fimi. [1] This domain may function as a carbohydrate binding module.
Algal cellulases are modular, consisting of putative novel cysteine-rich carbohydrate-binding modules (CBMs), proline/serine-(PS) rich linkers in addition to putative Ig-like and unknown domains in some members. Cellulase from Gonium pectorale consisted of two CDs separated by linkers and with a C-terminal CBM. [6]
Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. [ 5 ] [ 6 ] The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.
In molecular biology, the X8 domain, is thought to play a role in targeting the plasmodesmata by providing it with structural support. The domain is able to do this since it contains signal sequences for a glycosylphosphatidylinositol (GPI) linkage to the extracellular face of the plasma membrane.
This cellulose binding-site is not present in other CDH classes. The binding to cellulose in Class II CDHs depends on the presence of a C-terminal family 1 carbohydrate binding module (CBM1). Some Class II CDH feature a C-terminal CBM1 and are classified as Class IIA CDHs, whereas Class IIB CDHs have no CBM1 and do not bind to cellulose.
Several carbohydrate binding modules (CBM) have also been identified that are predicted to bind glycogen (CBM family 48); xylan or chitin (CBM family 2); and starch (CBM family 26). [ 21 ] [ 22 ] The genus Butyrivibrio encompasses over 60 strains that were originally confined to the species Butyrivibrio fibrisolvens based on their phenotypic ...