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The exact prevalence of obesity hypoventilation syndrome is unknown, and it is thought that many people with symptoms of OHS have not been diagnosed. [4] About a third of all people with morbid obesity (a body mass index exceeding 40 kg/m 2 ) have elevated carbon dioxide levels in the blood.
Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare condition whose etiology is currently unknown. [1] ROHHAD mainly affects the endocrine system and autonomic nervous system, but patients can exhibit a variety of signs.
obesity or being overweight; neuromuscular disease or any condition that entails weakened respiratory muscles; hypoventilation syndromes involving compromised or failed respiratory drive; use of sedatives, for example sleeping pills; hazardous alcohol use; smoking; aging; others, most of which are also typical causes of airway obstruction ...
[6] Central hypoventilation syndrome is caused by certain receptors in the brain failing to recognize changes in carbon dioxide levels during sleep, leading to a low breathing rate and low blood concentration of oxygen. Some of the causes of this disease are sudden onset obesity or spinal cord surgery.
Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed respiratory gas exchange. [1] By definition it causes an increased concentration of carbon dioxide ( hypercapnia ) and respiratory acidosis .
Chronic respiratory acidosis also may be secondary to obesity hypoventilation syndrome (i.e., Pickwickian syndrome), neuromuscular disorders such as amyotrophic lateral sclerosis, and severe restrictive ventilatory defects as observed in interstitial lung disease and thoracic deformities. [citation needed]
Death rate from obesity, 2019. Obesity is a risk factor for many chronic physical and mental illnesses.. The health effects of being overweight but not obese are controversial, with some studies showing that the mortality rate for individuals who are classified as overweight (BMI 25.0 to 29.9) may actually be lower than for those with an ideal weight (BMI 18.5 to 24.9). [1]
Acute hypercapnic respiratory failure may occur in acute illness caused by chronic obstructive pulmonary disease (COPD), chest wall deformity, some forms of neuromuscular disease (such as myasthenia gravis), and obesity hypoventilation syndrome. [12]